Kidney Stones Associated with Development of Chronic Kidney Disease

By Mohamad Hamze

            Doctors from the Mayo Clinic observed that kidney stone formation may have more than just the typically associated acute symptom of severe pain. Previously, no particular long term effects were studied alongside first-time kidney stone events, but a recent study of 384 first-time kidney stone formers revealed that the formation and passing of kidney stones for the first time can result in an increased risk of developing chronic kidney disease. Patients who experienced their first kidney stone were assessed following the event, undergoing urinalyses to determine the presence of cystatin C and urine protein. These individuals, even when adjusted for other risk factors including high blood pressure and obesity, were found to have higher levels of both, compared to their control counterparts three months following the symptoms – an indicator of decreased kidney function and increased risk of chronic kidney disease.

            Around seven percent of adults suffer from kidney stones. Nephrologists William Haley, M.D. and Andrew Rule, M.D. at the Mayo Clinic hope that this new research will help create a better understanding of the implications of kidney trauma and how to approach treatments going forward. They stress that prevention of kidney stones is important not only for the prevention of the severely painful acute symptoms, but also for the maintenance of long-term kidney health.


Mayo Clinic. "Research connects first-time kidney stone formers and chronic kidney disease." ScienceDaily. ScienceDaily, 2 November 2016. <>.