By Kaya Jordan
Researchers at the University of Georgia and a UGA startup company led by Steven Stice have developed a new regenerative stroke treatment that repairs brain damage. This will affect so many as strokes are the third leading cause of death in the United States. The treatment, AB126, relies on exosomes, which are fluid filled extracellular vesicles. Human neural stem cells are capable of producing these structures. They found that the small extracellular vesicles are perfect for storing and administering doses. The extracellular vesicles are more effective than cell therapy because of their small size, tubular shape and invisibility to the body's defense system. MRI studies found a decline in atrophy rate in rats that had been administered AB126. The scans showed "an approximately 35 percent decrease in the size of the injury and 50 percent reduction in brain tissue loss." The UGA start up, ArunA Biomedical is planning on starting clinical trials on humans as early as next year. The company is also hoping to use this method to treat other problems of the brain such as traumatic brain damage and epilepsy. Most exciting, these companies promise to produce these therapies at a low cost, revolutionizing not only the treatment of these brain disorders but possibly cancer, heart disease and more.
University of Georgia. (2018, February 15). New stem-cell based stroke treatment repairs damaged brain tissue: Human clinical trials could begin as early as next year. ScienceDaily. Retrieved February 25, 2018 from www.sciencedaily.com/releases/2018/02/180215105742.htm